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. 2017 Dec 8;7:509. doi: 10.3389/fcimb.2017.00509

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Copyright © 2017 Honig Mondekova, Sima, Urbanova, Kovar, Rego, Grubhoffer, Kopacek and Hajdusek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tick FRePs cluster into three groups designated as Ixoderin A, B, and C. An unrooted phylogenetic tree of the tick and related invertebrate FReP amino acid sequences, reconstructed using the Neighbor Joining (NJ) method and based on alignment using ClustalX. Full circles indicate genomic ixoderin sequences of I. scapularis. Numbers at branches represent bootstrap support using NJ criterion with 1,000 replicates each. Bar: 0.1 substitutions per site. Ixoderin A I. ricinus: AAQ93650 (AY341424), Ixoderin B I. ricinus: AAV41827 (AY643518), Ixoderin C I. ricinus: GCJO01000224. Alignment and full sequence descriptions are provided as Supplementary Data Sheet 1 and 2.