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. 2017 Dec 12;7:17403. doi: 10.1038/s41598-017-16540-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TRPP2 accelerates cytoskeletal inhibition of TREK1. (a) Representative traces showing mechanically-elicited TREK1 currents in cells exposed to a −70 mm Hg pressure pulse at 2 Hz and after 2 s, 15 s, and 30 s of rest. Cells were co-transfected with Mock (blue trace) or TRPP2 (red trace)-containing plasmids. Insets labeled A, B and C represent magnifications of the original trace before (A), at the 20^th pulse (B), and at the last pulse (C). (b) Normalized mechanically-evoked TREK1 current (mean ± s.e.m.) during (0–10 s) and after (10–57 s) the pressure pulse train in TRPP2 (n = 38) expressing and Mock (n = 40) cells. *Indicates significant difference from Mock-transfected group, p < 0.05; Two-way ANOVA with Tukey’s post-hoc test. (c) Recovered TREK1 current inhibition at 47 s post pressure pulse train showing a significant increase in TREK1 current inhibition when TRPP2 is expressed. All data expressed as a percentage to the 20th (final) pulse at 10 s. Statistical significance at *p < 0.05, one way ANOVA.