Table 3.

Grignard scope

Entry	R′MgX	R	Product	Yield (%)a	ee (%)b
1	EtMgBr	Ph	2a	94	93
2	PrMgCl	Ph	5a	75	93
3	HexMgBr	Ph	5b	81	95
4	i-PentMgBr	Ph	5c	65	97
5	i-BuMgBr	Hexyl	5d	56	64
6c	c-PentMgBr	Hexyl	5e	54	89
7	CH2=CH(CH2)2MgBr	Hexyl	5f	91	93
8	CH2=CH(CH2)3MgBr	Ph	5g	66	90
9	Ph(CH2)2MgBr	Hexyl	5 h	89	97
10d	MeMgBr	Hexyl	5i	50	93
11e	PhMgBr	Hexyl	5j	84	0

^aReported yields are for isolated products

^bDetermined by chiral HPLC

^c4. equiv. of Grignard was used

^dReaction was carried out at 0 °C for 5 h

^eLigand L10 was used (see Supplementary Table 1 for L10 structure)