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Biological characteristics of the wild-type and mutant viruses.
| Virus | Pathogenicity | Virus titer | ||
|---|---|---|---|---|
| ICPI scorea | MDT (h)b | Log10EID50/ml | Log10TCID50/ml | |
| WT | 1.86 | 42 | 8.64 | 9.00 |
| NPE402A | 1.81 | 36 | 9.37 | 8.57 |
aIntracerebral pathogenicity index (ICPI): virulent strains, 1.50–2.00; moderately virulent strains, 0.70–1.50; avirulent strains, 0.00–0.70.
bMean death time (MDT): virulent strains, < 60 h; moderately virulent strains, 60–90 h; avirulent strains, >90 h.
