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. 2017 Dec 12;7:17419. doi: 10.1038/s41598-017-17232-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Antibacterial mode of action studies with γ-ACT. (a) Impact of a 10 minute challenge with γ-ACT and comparator agents at 4XMIC on macromolecular synthesis in S. aureus SH1000. (b and c) Effect of γ-ACT and comparator agents at 4XMIC on the function and integrity of the cytoplasmic membrane of S. aureus SH1000, as measured respectively in (b) with the PMF-responsive probe, DiSC₃(5), and in (c) by monitoring leakage of K⁺ ions from cells. Values shown are the means of at least three independent experiments, with error bars representing standard deviations from the mean.