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. 2017 Dec 12;8:2094. doi: 10.1038/s41467-017-02350-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Negative association between NHEJ and type II-A CRISPR-Cas systems. a Distribution of the subtypes II-A and II-C in Proteobacteria and Firmicutes genomes. b Associations between NHEJ and subtypes II-A and II-C CRISPR-Cas systems. Expected values correspond to the number of co-occurrences that would be obtained if the systems were randomly distributed. c Presence of NHEJ and type II CRISPR-Cas systems in Firmicutes. A system is annotated as present in a given species when more than half of the genomes available for this species encode the system