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. 2017 Dec;25:233–244. doi: 10.1016/j.scr.2017.11.003

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© 2017 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 3 — Ajmaline blocks both I_Na and I_Kr in hiPSC-CMs.

A) Representative I_Na traces and current density (pA/pF) under control conditions and after application of ajmaline (100 μM), n = 15 cells. B) Representative traces showing the effect of application of ajmaline (100 μM) on I_Kr tail currents. The voltage protocol and scale are inset. C) Digital subtraction of the current blocked by ajmaline. D) In some cells the I_Kr tail current partially recovered after removal (washout) of ajmaline (indicated by arrow) and this could then be blocked by the addition of the I_Kr specific blocker dofetilide (1 mM). E) Current density before and after ajmaline application. F) Peak-tail current density (PTCD) before and after ajmaline application. * = p ≤ 0.05 (paired t-test) compared to baseline value before ajmaline addition, n = 8 cells. Data displayed as mean ± s.e.m.