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. 2017 Dec 12;7:17413. doi: 10.1038/s41598-017-17660-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of key model components. (a) The model domain included a plaque biofilm region adjacent to the enamel surface, and a more distant saliva region. Periodicity was assumed along the x and y-axes. (b) Graphical representation of the glycolytic rates for cell types A and NA, with a saturation factor for glucose availability ([Gl] of either [intakeGl] or [polyGl]), and an optimum pH of 5 and 7 for A and NA, respectively. Cellular growth was proportional to the glycolytic rates. (c) Schematic representation of periodic sugar intake showing two different frequencies, one pulse every 3 hours (black) and once every 6 hours (grey), with the same total amount. The constant, low concentration of [polyGl] is also shown. A = aciduric; NA = non-aciduric.