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. 2017 Dec 12;7:17442. doi: 10.1038/s41598-017-17045-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Regulatory network of arginine and proline metabolisms. Green boxes and yellow box represent the enriched DEGs (green includes up-regulated gene, yellow includes both up-regulated and down-regulated genes). The pathway map without coloring is the original version that is manually drawn by in-house software named KegSketch. White boxes are hyperlinked to KO, ENZYME, and REACTION entries in metabolic pathways, and to KO and GENES entries in non-metabolic pathways. Purple boxes are hyperlinked to KO entries that are selected from the original version.