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. 2017 Dec 12;7:17364. doi: 10.1038/s41598-017-17351-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Heatmap generated by unsupervised hierarchical clustering analysis of cervical microbiomes of the studied participants. CSTs were defined using clustering based on Bray-Curtis dissimilarity and average linkage and are shown in color-coded groups at the bottom and also by the dendrogram at the top of the Figure. HPV status, cervical cytology and postpartum period are also color-coded according to the legend at the right of the Figure. CST III is L. iners-dominant; CST IV-A has a low proportion of Lactobacillus and a high diversity; CST IV-B.1 is G. vaginalis-dominant and CST IV-B.2 is Prevotella-dominant. All taxa shown in the graph presented relative abundance >1%.