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. 2017 Dec 12;7:17435. doi: 10.1038/s41598-017-17582-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time evolution of the maximum signal of different compartments in phantom and in brain after each RF pulse. (a–d) Comparison of simulated (blue) and measured (black) maximum magnitude ²³Na signals after each pulse of the 15-pulse FLORET sequence for (a) 0% agar phantom compartment, showing a correlation of 0.99, (b) 4% agar phantom compartment, with a correlation of 0.95, (c) 8% agar phantom compartment with a correlation of 0.95, and (d) cerebrospinal fluid (CSF) in the brain, showing a correlation of 0.99. The 15-point signals were all normalized to the the maximum signal point in each compartment. (e,f) Absolute sodium signals over 15 pulses as simulated for three compartments in the brain: CSF, intracellular (IC), and extracellular (EC), before (e) and after (f) frequency offset and $B_{1}^{+}$ correction procedures. See Table 1 for corresponding correlation coefficients between these three signals.