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. 2017 Dec 12;7:17435. doi: 10.1038/s41598-017-17582-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Examples of ¹H and ²³Na images in brain of a healthy volunteer: transverse, sagittal and coronal slices. The proton MPRAGE image was acquired with 1.25 mm isotropic resolution. The sodium (single) FLORET was acquired with 10 average and 5 mm isotropic resolution. The sodium multi-FLORET image is the sum of the 15 images acquired with the 15-pulse (multi) FLORET with 4 averages and 5 mm isotropic resolution. Both FLORET and multi-FLORET show comparable quality and resolution, but slightly different contrast due to the different contrast of each individual multi-FLORET acquisition. See Methods for acquisition details.