Table 1.
Physiological status of Sprague–Dawley rats used for 20 min intrarenal administration of GLP‐1
| Control (n = 9) | BSA 20 min | Control (n = 19) | GLP‐1 20 min | Control (n = 6) | GLP‐1 + Ex 20 min | |
|---|---|---|---|---|---|---|
| MAP (mmHg) | 104 ± 2 | 103 ± 3 | 111 ± 2 | 113 ± 2b | 117 ± 6 | 116 ± 6 |
| RBF (mL/min) | 7.2 ± 0.7 | 7.8 ± 0.9 | 8.6 ± 0.7 | 9.9 ± 0.8b | 9.0 ± 1.6 | 9.3 ± 1.6 |
| HR (BPM) | 354 ± 8 | 356 ± 9 | 346 ± 10 | 343 ± 13 | ||
| V U (μL/min) | 12.1 ± 1.7 | 19.1 ± 2.8 | 30.6 ± 1.9 | 76.5 ± 10.8b | 27.6 ± 2.4 | 53.2 ± 18.1b |
| UNa+ (μmol/min) | 2.8 ± 1.3 | 5.1 ± 1.3 | 4.0 ± 1.2 | 12.6 ± 1.8b | 3.6 ± 1.0 | 8.2 ± 4.4a |
| UK+(μmol/min) | 2.7 ± 0.2 | 2.3 ± 0.2 | 3.5 ± 0.3 | 3.6 ± 0.9 | 2.7 ± 0.3 | 2.5 ± 0.2 |
| Insulin (μg/L) | 2.1 ± 0.2 | 2.7 ± 0.4 |
Values are mean ± SE. HR, heart rate; BPM, beats per min; V u: urine flow rate; UNa+, urinary sodium excretion rate; UK+, urinary potassium excretion rate.
a
P < 0.05 versus control.
b
P < 0.01 versus control.