Table 2.
Physiological status of SHR rats used for 20 min intrarenal administration of GLP‐1
| Control (n = 5) | BSA 20 min | Control (n = 10) | GLP‐1 20 min | Control (n = 6) | GLP‐1 + Ex 20 min | |
|---|---|---|---|---|---|---|
| MAP (mmHg) | 158 ± 9 | 159 ± 8 | 167 ± 9 | 178 ± 10a | 167 ± 5 | 167 ± 5 |
| RBF (mL/min) | 4.1 ± 0.4 | 3.9 ± 0.5 | 4.4 ± 0.7 | 5.1 ± 0.8a | 4.4 ± 0.4 | 4.6 ± 0.5 |
| HR (BPM) | 288 ± 6 | 287 ± 6 | 286 ± 7 | 288 ± 6 | ||
| V U (μL/min) | 10.1 ± 2.3 | 13.3 ± 3.2 | 13.9 ± 1.9 | 24.8 ± 7.8a | 13.0 ± 3.0 | 19.5 ± 3.1a |
| UNa+ (μmol/min) | 1.8 ± 0.6 | 2.5 ± 0.8 | 2.0 ± 0.5 | 4.2 ± 1.3a | 2.6 ± 0.9 | 3.7 ± 0.9a |
| UK+(μmol/min) | 1.2 ± 0.2 | 1.1 ± 0.2 | 1.3 ± 0.1 | 1.3 ± 0.1 | 1.3 ± 0.2 | 1.4 ± 0.2 |
| Insulin (μg/L) | 1.8 ± 0.2 | 4.2 ± 0.8b |
Values are mean ± SE.
HR, heart rate; BPM, beats per min; V u, urine flow rate; UNa+, urinary sodium excretion rate; UK+, urinary potassium excretion rate.
a
P < 0.01 versus control.
b
P < 0.05 versus BSA.