Table 2.
Results of stepwise Cox multivariate regression models for OS of CRC patients with liver metastasis
| Covariate | Univariate | Multivariate | |
|---|---|---|---|
| P‐value | P‐value | HR (CI) | |
| Gender | 0.017 | ||
| Age (65 years) | 0.083 | ||
| Tumor location | 0.149 | ||
| Numbers of liver metastases | 0.322 | ||
| CEA level | 0.003 | 0.007 | 3.056 (1.354–6.897) |
| CA19‐9 level | 0.469 | ||
| Extra‐nodal tumor deposits | 0.049 | ||
| Lymphovascular invasion | 0.009 | 0.054 | 3.055 (0.981–9.512) |
| Ascites | 0.165 | ||
| Obstruction | 0.766 | ||
| Treatment strategy | <0.001 | 0.023 | 0.212 (0.056–0.808) |
| CD133+ subpopulation | 0.069 | ||
| CD54+ subpopulation | 0.931 | ||
| CD44+ subpopulation | 0.966 | ||
| CD133+CD44− subpopulation | 0.962 | ||
| CD133+CD44+ subpopulation | 0.069 | ||
| CD133−CD44+ subpopulation | 0.206 | ||
| CD133+CD54− subpopulation | 0.981 | ||
| CD133+CD54+ subpopulation | <0.001 | 0.079 | 4.838 (0.834–28.078) |
| CD133−CD54+ subpopulation | 0.004 | ||
| CD54+CD44− subpopulation | 0.437 | ||
| CD54+CD44+ subpopulation | 0.538 | ||
| CD54−CD44+ subpopulation | 0.542 | ||
| CD133+CD44+CD54− subpopulation | 0.165 | ||
| CD133+CD44+CD54+ subpopulation | 0.003 | 0.014 | 6.459 (1.461–28.558) |
| CD133+CD44−CD54+ subpopulation | 0.774 | ||