Figure 1.

Overview of β‐catenin‐dependent Wnt signalling. (A) In the absence of Wnt, β‐catenin is bound by the ‘destruction’ complex and phosphorylated by GSK3 and casein kinase I (CKI). Phosphorylation results in targeting for ubiquitin‐mediated degradation. (B) Wnt binding to a FZD receptor and the LRP5/6 co‐receptor disrupts the ‘destruction’ complex and stabilizes β‐catenin. The β‐catenin protein translocates to the nucleus, interacts with T‐cell factor/lymphoid enhancer factor (TCF/LEF) family transcription factors and activates a Wnt‐responsive transcriptional programme. β‐TrCP, β‐transducin repeat containing protein; DVL, Dishevelled.