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. 2017 Jul 7;174(24):4637–4650. doi: 10.1111/bph.13894

Figure 2.

Figure 2

DKK1 regulation of signalling pathways. (A) DKK1 inhibition of β‐catenin‐dependent Wnt signalling. DKK1 inhibits β‐catenin‐dependent Wnt signalling by binding to the LRP5/6 co‐receptor and blocking Wnt binding, which results in β‐catenin degradation. (B) Model of DKK1 activation of β‐catenin‐independent Wnt signalling. DKK1 binding to the LRP5/6 co‐receptor shifts Wnt and the FZD receptor to β‐catenin‐independent signalling pathways. A simplified version of the β‐catenin‐independent Wnt/PCP pathway is shown as an example. (C) DKK1 activation of a non‐Wnt signalling pathway. DKK1 binds to the CKAP4 receptor and activates PI3K/Akt signalling. GSK3, glycogen synthase kinase 3; CKI, casein kinase I; β‐TrCP, β‐transducin repeat containing protein; RYK, receptor‐like tyrosine kinase; DVL, Dishevelled; ROCK, Rho‐associated protein kinase.