Figure 8.

Effects of the incubation of cortical synaptosomes with an anti‐mGlu₂ receptor or anti‐mGlu₃ receptor antibody on the 12 mM KCl/LY379268‐evoked release of [³H]‐D‐Asp. The 12 mM KCl‐evoked release of tritium amounted to the following: control synaptosomes, 1.48 ± 0.43 nCi; anti‐mGlu₂ antibody‐incubated synaptosomes, 1.63 ± 0.27 nCi; and anti‐mGlu₃ antibody‐incubated synaptosomes 1.48 ± 0.29 nCi. Results are expressed as percentage of the 12 mM KCl‐evoked [³H]‐D‐Asp release (% of control). Data are the mean ± SEM of n (number within brackets) experiments ^* P < 0.05 versus the 12 mM KCl‐evoked tritium overflow from control cortical synaptosomes; °P < 0.05 versus the 12 mM KCl/3 nM LY379268‐evoked tritium overflow from control cortical synaptosomes; ^# P < 0.05 versus the 12 mM KCl‐evoked tritium overflow from cortical synaptosomes incubated with the anti‐mGlu₃ receptor antibody; ^§ P < 0.05 versus the 12 mM KCl/3 nM LY379268‐evoked tritium overflow from control cortical synaptosomes.