Table 3.
Significant metabolites in sorafenib treated tissues compared to vehicle treated (control) tissues
| Heart | Liver | Skeletal Muscle | Serum |
|---|---|---|---|
| AMP | Acetoacetate/2‐Aminoisobutanoic acid | Adenosine/Inosine | Adenine |
| Dehydroalanine possibly from cysteine | Adenosine/Inosine | Aminomalonic acid | Malic acid |
| Ethanolamine | α‐Monostearin | Campesterol | Methionine sulfoxide |
| Glutamine | Aminomalonic acid | Dehydroalanine possibly from cysteine | Myoinositol‐2‐phosphate |
| Glycerol‐1‐phosphate | Asparagine | Hypotaurine | |
| Hypotaurine | Creatinine | ||
| Myoinositol‐2‐phosphate | Erythritol/Theitol | ||
| O‐Phosphocolamine | Hydroxyprolines | ||
| Stearamide | Proline | ||
| Taurine | Squalene | ||
| Stearamide | |||
| Succinic acid | |||
| Tetradecanedioic acid | |||
| Tyrosine |
Colour‐matched metabolites are highlighted if they (or they and closely related metabolites) were found in two or more tissues.