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. Author manuscript; available in PMC: 2017 Dec 13.
Published in final edited form as: Virology. 2016 Dec 10;502:13–19. doi: 10.1016/j.virol.2016.12.008

Table 1.

Influenza viruses tested for infectivity by the ocular route in mice.

Subtype IVPIa Virus name Isolate source # inocb # infc References
H7N2 LPAI A/New York/107/2003 Human respiratory case 6 0 (Belser et al., 2009b)
H7N2 LPAI A/chicken/Connecticut/260413-2/2003 avian 6 0 this study
H7N3 HPAI A/Canada/504/2004 Human conjunctivitis case 21 16 (Belser et al., 2012b, 2009b)
H7N3 LPAI A/Canada/444/2004 Human conjunctivitis case 12 10 (Belser et al., 2009b)
H7N3 LPAI A/Red Knot/New Jersey/1523470/2006 avian 6 1 (Belser et al., 2013a)
H7N3 HPAI A/Mexico/InDRE7218/2012 Human conjunctivitis case 16 15 (Belser et al., 2013a)
H7N7 HPAI A/Netherlands/219/2003 Human fatal case 20 20 (Belser et al., 2012b, 2009b)
H7N7 HPAI A/Netherlands/230/2003 Human conjunctivitis case 12 8 (Belser et al., 2009b)
H7N7 HPAI A/chicken/Netherlands/1/2003 avian 6 2 (Belser et al., 2009b)
H7N8 HPAI A/turkey/Indiana/1403/2016 avian 9 1 (Sun et al., 2016a)
H7N8 LPAI A/turkey/Indiana/1573-2/2016 avian 10 0 (Sun et al., 2016a)
H7N9 LPAI A/goose/Nebraska/17096-1/2011 avian 6 4 (Belser et al., 2013a)
H7N9 LPAI A/shoveler/Egypt/00215-NAMRU3/2007 avian 6 3 (Belser et al., 2013b)
H7N9 LPAI A/Anhui/1/2013 Human fatal case 14 12 (Belser et al., 2016, 2013b)
H7N9 LPAI A/Shanghai/1/2013 Human fatal case 6 5 (Belser et al., 2013b)
H7N9 LPAI A/Taiwan/1/2013 Human respiratory case 6 6 (Belser et al., 2016)
H7N9 LPAI A/Hong Kong/5942/2013 Human respiratory case 6 6 (Belser et al., 2016)
H7N9 LPAI A/British Columbia/1/2015 Human respiratory case 8 7 (Belser et al., 2016)
H5N1 HPAI A/Hong Kong/483/1997 Human fatal case 12 9 (Belser et al., 2009b)
H5N1 HPAI A/Hong Kong/486/1997 Human respiratory case 10 0 (Belser et al., 2009b)
H5N1 HPAI A/Hong Kong/213/2003 Human respiratory case 6 0 (Belser et al., 2009b)
H5N1 HPAI A/Vietnam/1203/2004 Human fatal case 10 4 (Belser et al., 2009b)
H5N1 HPAI A/Thailand/16/2004 Human fatal case 12 9 (Belser et al., 2009b)
H5N1 HPAI A/Indonesia/5/2005 Human fatal case 6 1 this study
H3N2 N/A A/Aichi/1/1968 Human respiratory case (seasonal) 6 1 (Belser et al., 2009b)
H3N2 N/A A/Memphis/102/1972 Human respiratory case (seasonal) 6 0 (Belser et al., 2009b)
H1N1 N/A A/South Carolina/1/1918 Reconstructed 1918 pandemic virus 6 3 (Belser et al., 2009b)
H1N1 N/A A/South Carolina/1/1918-AV Reconstructed 1918 pandemic virus 6 0 (Belser et al., 2009b)
H1N1 N/A A/New Jersey/8/1976 Human respiratory case (seasonal) 6 0 (Belser et al., 2010)
H1N1 N/A A/Ohio/2/2007 Human respiratory case (triple reassortant swine) 6 0 (Belser et al., 2010)
H1N1 N/A A/California/4/2009 Human respiratory case (2009 pandemic) 6 0 (Belser et al., 2011a)
H1N1 N/A A/California/4/2009-222G Point mutant of 2009 pandemic virus 6 0 (Belser et al., 2011a)
H1N1 N/A A/Mexico/4108/2009 Human respiratory case (2009 pandemic) 6 0 (Belser et al., 2010)
H1N1 N/A A/Mexico/4482/2009 Human respiratory case (2009 pandemic) 6 0 (Belser et al., 2010)
a

IVPI, intravenous pathogenicity index. HPAI, highly pathogenic avian influenza; LPAI, low pathogenic avian influenza. N/A, not applicable.

b

Total number of mice inoculated (inoc) by the ocular route with 106 PFU or EID50/5μl of virus.

c

Number of mice infected (inf) following ocular inoculation, defined by detection of infectious virus in the eye, nose, or lung through day 6 post inoculation.