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. 2017 Dec 13;8:2103. doi: 10.1038/s41467-017-02282-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — mRNA translation stress on EBNA1 polysomes activates PI3Kδ and E2F1 synthesis. Translation attenuation in cis caused by the GAr sequence of the EBNA1 mRNA causes translation stress, which results in activation of PI3Kδ and the induction of E2F1 mRNA translation independent of AKT and mTOR pathways. The newly synthesised E2F1 induces downstream target genes, including cyclins and c-myc, resulting in an increase in cell growth and proliferation