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Ldlr−/− reduces experimental autoimmune encephalomyelitis (EAE) severity in female but not in male mice. Daily EAE score of female [p < 0.0079; wild-type (WT) vs ldlr−/− by two-way ANOVA] (n = 19–20, pooled from three independent experiments) (A) and male (p < 0.2221; WT vs ldlr−/− by two-way ANOVA) (n = 5) (B) mice. The mean score [t(31) = 3.050; p < 0.0048] (C), the maximum score [t(37) = 2.349; p < 0.0244] (D), and the day of onset of the disease [t(29) = 1.848; p < 0.0748] (E).
