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. 2017 Dec 13;7:17523. doi: 10.1038/s41598-017-17679-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Immunohistochemical (IHC) staining of CaD and OPN in tissues specimens from NFPA patients (10 from NBD-NFPA patients and 28 from BD-NFPA patients). (A) IHC staining of CaD in NFPA without bone destruction, shows that CaD is expressed mainly in tumor stromal cells, especially in the vascular endothelial cells and fibroblasts. (B) IHC staining of CaD in NFPA with bone destruction shows much stronger staining in tumor stroma and positive staining in the cytoplasm of adenoma cells. (C) IHC staining of OPN in NFPA without bone destruction, shows weak positive staining in the cytoplasm of adenoma cells and tumor stroma. Much stronger staining can be being in NFPA with bone destruction (D). (A–D) With original magnification 200x; inner box: original magnification 400x). (E,F) Comparison of the IHC stain integrated optical density [log (IOD)] of CaD (E) and OPN (F) in NBD-NFPA and BD-NFPA specimens. (G) Scatter Plots shows positive correlation between IHC stain integrated optical density [log (IOD)] of CaD and OPN in NFPA specimens.