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. 2017 Dec 13;7:17514. doi: 10.1038/s41598-017-17819-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The benzothiazepine S107 reverses arrhythmia in the UNC-68(R4743C) mutant. (a) Original kymographs of video-microscopic recordings of the unc-68(r1162) rescue with wt and R4743C mutant fosmids, with or without incubation in 50 µM of the benzothiazepine S107 (inset) in 0.1% DMSO. (b) Mean and SEM number of pumps achieved over 100 consecutive light stimuli (3.7 Hz, 35 ms), binned per 10 light pulses, obtained by kymographic video analysis of intact, pmyo-2::ChR2::mCherry-expressing animals. As indicated, unc-68(r1162) deletion mutants, after 30 min incubation in 50 µM S107 (red) or without S107 (0.1% DMSO; black), were compared to wt with (green) or without (blue) S107 incubation (n = 4–9). (c) Analysis as in (b), but for r1162 deletion mutants expressing the R4743C fosmid, with S107 (green) or without (blue), or the rescue wt fosmid (red and black, respectively) (n = 20–29). (d) Percentage of successful light pulses followed by a pump, across all 100 light stimuli, as recorded in (b) and (c). Statistically significant differences, 1-way ANOVA and Bonferroni post-hoc test: ***p < 0.001; **p < 0.01; *p < 0.05.