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. 2017 Dec 13;7:17485. doi: 10.1038/s41598-017-17730-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Modulating levels of SOCS1 in CEFs and DF-1 regulates viral RNA expression and virus yield. (A) Titres of IBDV PBG98 recovered from CEFs and DF-1 after transient transfection with a SOCS1 expression plasmid or siSOCS1, respectively. Virus titres are the sum of cell-associated and extracellular virus, determined by plaque assay on CEFs (Mean ± SEM). (B) Fold change (percent) of IBDV VP4 RNA levels in CEFs and DF-1 after transient transfection with a SOCS1 expression plasmid or siSOCS1, respectively. Virus titres and viral RNA levels were compared with those from cells transfected with empty vectors or control siRNA, as appropriate. Data are representative from three independent experiments. An unpaired t-test with Welch’s correction (Two-tailed) was used to analyse the data. **P < 0.01, ****P < 0.0001.