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. 2017 Dec 13;7:17487. doi: 10.1038/s41598-017-17832-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HS-27 uptake is increased in aggressive breast tumor types in vivo. (a and b) Representative transmission and fluorescence images from tumor (MDA-MB-231 and BT-474) and non-tumor bearing window chambers in mice injected with either 20 mg/kg HS-27 (A) or 0.1 mL of 6 mM 2-NBDG (b). Transmission images are shown for reference of the tumor location. Scale bar is 2 mm. (c) Representative HS-27₆₀ or 2-NDBG₆₀/R_D images for MDA-MB-231 and BT-474 window chambers. (d) Average HS-27₆₀ and 2-NBDG₆₀/R_D were plotted against each other, revealing a strong correlation between the two endpoints (R² = 0.96), red = MDA-MB-231, cyan = BT-474, and black = non-tumor window chambers. For HS-27 imaging, n = 3 for all groups. For 2-NBDG imaging, n = 3 for tumor groups, and n = 8 for normal groups.