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. 2017 Dec 13;7:17487. doi: 10.1038/s41598-017-17832-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ex vivo HS-27 application retains contrast between tumor and non-tumor tissue. (a) Sample images of mouse tumor tissue treated ex vivo with 100 µM HS-27 or 100 µM inactivated HS-27 (HS-217) for one minute (b) Probability distribution functions (PDFs) of the HS-27 (n = 3) and HS-217 (n = 3) fluorescence values demonstrate significantly greater fluorescence in HS-27 treated samples than HS-217 treated samples. (c) Sample images of mouse tumor tissue and mouse skin tissue treated ex vivo with 100 µM HS-27 for one minute (d) PDFs of the HS-27 fluorescence values for both tumor (n = 3) and non-tumor (n = 3) are shown beneath the images. Fluorescence was significantly greater in tumor than non-tumor samples. (e) Sample images of tumor or non-tumor mouse tissue at 60-minutes after i.v. injection of 20 mg/kg HS-27. (f) PDFs of HS-27 fluorescence values for both tumor (n = 3) and non-tumor (n = 3) demonstrate significantly greater fluorescence in tumor than non-tumor samples. P-values were calculated using a Kolmogorov Smirnov test.