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. 2017 Dec 13;7:17496. doi: 10.1038/s41598-017-17406-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Enhancing Kv3.1 currents through bath application of AUT00063 modifies action potential characteristics and improves spike timing precision. Current clamp recordings were made from individual fusiform neurons in an acute slice preparation of the dorsal cochlear nucleus. (a) Examples of fusiform neuron action potential (AP) waveforms in response to a single current step (800 pA at 0.6 Hz) in the presence of a control solution (0.1% DMSO, black) or AUT00063 (30 µM, gray). (b) Action potential variability, measured as the coefficient of variation (CV) in peak latency is significantly reduced with AUT00063. (c–f) Some aspects of AP shape including peak amplitude (c) and peak negativity of the afterhyperpolarization (d) were significantly modified by AUT00063, whereas AP halfwidth (e) and rise time (f) wre not. Data in B-F present individual fusiform neurons as single data points alongside the mean ± s.e.m. Asterisks indicate p < 0.05 with an unpaired t-test.