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. 2017 Dec 13;7:17496. doi: 10.1038/s41598-017-17406-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

A numerical simulation suggests that increased Kv3.1 currents improves spike synchronization to periodic synaptic inputs. (a) A simplified computer model based on voltage-dependent Na⁺ and K⁺ currents was used to predict firing patterns (V) in response to a 20 Hz train of synaptic inputs (Gsyn). The effects of AUT00063 were simulated by computationally mixing low-threshold current from AUT-modified channels to the normal high-threshold Kv3.1 currents at levels ranging from 0–100%. (b) Precise synchronization to the 20 Hz synaptic input, as estimated from the vector strength statistic, improves with the addition of modified low-threshold Kv3.1 currents.