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. 2017 Dec 13;7:17496. doi: 10.1038/s41598-017-17406-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AUT00063, a novel Kv3.1 channel modulator, improves temporal coding in the IC as measured via responses to chirp train stimuli 30 days after ouabain. (a) Example PSTH from a multiunit recording in the ICc of a ouabain-treated mouse with vehicle (left, green trace) or AUT00063 (right, purple trace) injected systemically 20–25 minutes prior to recording. Stimulus is a 10 Hz chirp train presented at 20 dB above threshold. (b) Same as (a), but the stimulus is a 160 Hz chirp train. (c) Example raster plots of multiunit spiking responses across trials of chirp trains of various frequencies, with systemic delivery of vehicle (green rasters) or AUT00063 (purple rasters, n = 73 recording sites in both conditions in ICc). (d) Average vector strength of all significantly sound responsive sites across chirp train frequency, with and without AUT00063. (e) Probability of correct classification of chirp train frequency with increasing PSTH bin sizes for IC multiunit responses (significantly responding to sound), with and without AUT00063. (f) Same as (e), but for ACtx (n = 61 sites).