Table 2.
Presence of mutations, amplifications, delections and other alterations in the 29 identified breast cancer genes using data from TCGA, contained at cBioportal.
| 816 Breast Invasive Carcinoma Samples | ||||
|---|---|---|---|---|
| Gene Name | Amplification | Deletion | Mutation | Other alterations |
| KLHL13. Kelch-like protein 13 | 0.5% | 0.1% | 0.5% | — |
| HUWE1. HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 1.2% | 0.4% | 3.3% | 0.1% |
| ITCH. Itchy E3 ubiquitin protein ligase | 1.8% | 0,1% | 0.5% | — |
| KLHDC7A. Kelch domain containing 7A | 0.1% | 0.7% | 0.2% | — |
| UBE2C. Ubiquitin-conjugating enzyme E2 C | 3.7% | 0.1% | — | — |
| UBE2T. Ubiquitin-conjugating enzyme E2 T | 12% | — | 0.1% | 0.1% |
| UBE2S. Ubiquitin-conjugating enzyme E2 S | 2.7% | 0.1% | 0.1% | — |
| UBE2H. Ubiquitin-conjugating enzyme E2 H | 1% | — | — | — |
| UBASH3B. Ubiquitin-associated and SH3 domain-containing protein B | — | 1.3% | 0.1% | — |
| TRIM71. E3 ubiquitin-protein ligase TRIM71 | 0.6% | 0.2% | 0.4% | — |
| TRIM68. E3 ubiquitin-protein ligase TRIM68 | 0.2% | 0.9% | 0.2% | — |
| TRIM63. E3 ubiquitin-protein ligase TRIM63 | 0.2% | 0.2% | 0.1% | — |
| NEDD4L. E3 ubiquitin-protein ligase NEDD4-like | 0.7% | 1.1% | 0.9% | — |
| N4BP1. NEDD4-binding protein 1 | 1.7% | 0.6% | 0.5% | — |
| PELI2. E3 ubiquitin-protein ligase pellino homolog 2 | 0.7% | 0.1% | 0.5% | — |
| RNF130. E3 ubiquitin-protein ligase RNF130 | 1.2% | 0.1% | 0.1% | — |
| SOCS2. Suppressor of cytokine signaling 2 | 1.2% | 0.1% | 0.1% | — |
| SIAH1. E3 ubiquitin-protein ligase SIAH1 | 1.8% | 0.7% | 0.2% | — |
| TULP4. Tubby-related protein 4 | 0.7% | 0.6% | 0.6% | 0.1% |
| CDCA3. Cell division cycle-associated protein 3 | 3.4% | 0.1% | 0.1% | — |
| CDC20. Cell division cycle-associated protein 20 | 1.8% | — | 0.2% | — |
| CCDC50. Coiled-coil domain-containing protein 50 | 2.9% | 0.2% | 0.5% | — |
| FBXO32. F-box only protein 32 | 18.4% | — | — | — |
| FBXL22. F-box and leucine-rich protein 22 | 0.6% | 0.1% | — | — |
| FBXO11. F-box only protein 11 | 0.7% | 0.1% | 0.6% | — |
| DTL. Denticleless protein homolog | 11.9% | — | 0.1% | — |
| LNX1. E3 ubiquitin-protein ligase LNX | 0.7% | — | 0.7% | — |
| SH3RF2. Putative E3 ubiquitin-protein ligase SH3RF2 | 0.2% | 0.1% | 0.1% | — |
| UHRF1. E3 ubiquitin-protein ligase UHRF1 | 1.5% | 0.1% | — | — |