Fig. 11.

Immunolabeled images in heart, liver (left) and kidney (right) and lipid staining in liver (left) with quantitative analysis for their labeling intensity in control (Cont) and CM-treated (CM) rats. (A-D) Arrowheads and arrows indicate intercalated disks and Z bands, respectively, in cardiomyocytes. In the liver (E-L), immunostaining with the respective antibodies ((E-J) and lipid staining (K, L). In the kidney (M-V), epithelial cells of renal tubules (arrows) are labeled, but glomerular structures (asterisks) are not significantly labeled. CD, cathepsin D. Values from control rats are expressed as a mean value of 100 in arbitrary units (AU). Significant differences in expression in CM-treated rats compared with that in control rats are shown as * P < 0.05, ** P <0.01. Scales, 50 μm in A-D for the heart, in E-L for the liver, in M-V for the kidney.