Table II.
Molecular properties of the 20 HUB nodes specific for HepG2 that are common to the circadian network.
| Gene name | Protein code | Protein name | IDR | INT | SEQ |
|---|---|---|---|---|---|
| AURKB | Q96GD4 | Aurora kinase B | ++ | 268 | 344 |
| BIRC5 | O15392 | Baculoviral IAP repeat-containingprotein 5 | +++ | 137 | 142 |
| CDC20 | Q12834 | Cell division cycle protein 20 homolog | ++ | 595 | 499 |
| CENPA | P49450 | Histone H3-like centromeric protein A | ++ | 129 | 140 |
| CHEK1 | O14757 | Serine/threonine-protein kinase Chk1 | ++ | 161 | 476 |
| CKAP5 | Q14008 | Cytoskeleton associated protein 5 | +++ | 39 | 2032 |
| CSNK2A1 | P68400 | Casein kinase II subunit alpha | ++ | 599 | 391 |
| HLA-B | P01889 | HLA class I histocompatibility antigen, B-7 alpha chain | ++ | 63 | 362 |
| INCENP | Q9NQS7-INCE human | Inner centromere protein | +++ | 17 | 918 |
| KIF2C | Q99661 | Kinesin-like protein KIF2C | ++ | 82 | 725 |
| MAD2L1 | Q13257 | Mitotic spindle assembly check point protein MAD2A | + | 48 | 205 |
| MCM3 | P25205 | DNA replication licensing factor MCM 3 | ++ | 171 | 808 |
| MCM4 | P33991 | DNA replication licensing factor MCM 4 | ++ | 152 | 863 |
| MCM6 | Q14566 | DNA replication licensing factor MCM 6 | ++ | 160 | 821 |
| RFC4 | P35249 | Replication factor C subunit 4 | + | 68 | 363 |
| SFN | P31947 | 14-3-3 protein sigma | +++ | 305 | 248 |
| SPC24 | Q8NBT2 | Kinetochore protein Spc24 | +++ | 31 | 197 |
| SRC | P12931 | Proto-oncogene tyrosine-protein kinase Src | ++ | 272 | 536 |
| UBD | 15205 | Ubiquitin D | +++ | 667 | 165 |
| ZWINT | 95229 | Zw10- interactor | + | 55 | 277 |
IDR, intrinsically disordered region; +, IDR <15%; ++, IDR 15–50%; +++, IDR >50%; INT, number of interactions with molecular partners (determined using BioGRID); SEQ, sequence length (number of amino acids); AURKB, Aurora kinase B; BIRC5, Baculoviral IAP repeat-containing protein 5; CDC20, Cell division cycle protein 20 homolog, CENPA, histone H3-like centromeric protein A; CHEK1, serine/threonine-protein kinase Chk1; CKAP5, cytoskeleton-associated protein 5; CSNK2A1, casein kinase II subunit-α; HLA-B, HLA class I histocompatibility antigen, B-7 α-chain; INCENP, inner centromere protein; KIF2C, Kinesin-like protein; MAD2L1, mitotic arrest deficient 2 like 1; MCM3, minichromosome maintenance complex component 3; RFC4, replication factor C subunit 4; SFN, 14–3–3 protein-σ; SPC24, kinetochore protein Spc24; SRC, proto-oncogene tyrosine-protein kinase Src; UBD, ubiquitin D; ZWINT, Zw10 interactor.