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. 2017 Oct 19;14(6):7715–7722. doi: 10.3892/ol.2017.7223

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Effects of CH or IH on MDA-MB-231 cell migration and proliferation. MDA-MB-231 cells were exposed to IH, CH or N. (A) A wound-healing assay revealed that the IH group exhibited accelerated migration compared with the CH and N groups. (B) The relative mobility was calculated from the wound healing assay data. (C) A Transwell migration assay revealed that the proportion of cells migrating to the lower chamber in the IH group was significantly increased compared with the CH or N group. (D) The relative levels of cell migration were calculated. (E) A Cell Counting Kit-8 assay revealed that the IH group exhibited reduced proliferative activity compared with the N group. The CH group also exhibited reduced proliferative activity; however, this was not obvious until the 3rd day of culture. Data are expressed as the mean ± standard deviation of three repetitions. *P<0.05 vs. IH group; **P<0.01 vs. IH group. IH, intermittent hypoxia; CH, continuous hypoxia; N, normoxia.