Table II.
LGR5 expression and clinicopathological features.
| LGR5+ (n=36) | LGR5- (n=20) | ||||
|---|---|---|---|---|---|
| Characteristic | n | % | n | % | P-value |
| Gender | |||||
| Male | 25 | 69.4 | 12 | 60.0 | 0.48 |
| Female | 11 | 37.9 | 8 | 29.6 | |
| Mean age ± SD (years) | 60.2±11.1 | 62.8±7.1 | 0.51 | ||
| pT stage | |||||
| T1-2 | 15 | 42.0 | 6 | 30.0 | 0.38 |
| T3-4 | 21 | 58.0 | 14 | 70.0 | |
| Histological type | |||||
| Pap, Well | 24 | 66.7 | 15 | 75.0 | 0.51 |
| Mod, Por, Muc | 12 | 33.3 | 5 | 25.0 | |
| Lymphatic invasion | |||||
| Present | 5 | 13.9 | 0 | 0.0 | 0.03 |
| Absent | 31 | 86.1 | 20 | 100.0 | |
| Vascular invasion | |||||
| Present | 19 | 52.8 | 12 | 60.0 | 0.60 |
| Absent | 17 | 47.2 | 8 | 40.0 | |
| Lymph node metastasis | |||||
| Present | 9 | 25.0 | 0 | 0.0 | <0.01 |
| Absent | 27 | 75.0 | 20 | 100.0 | |
| Distant metastasis | |||||
| Present | 5 | 13.9 | 1 | 5.0 | 0.28 |
| Absent | 31 | 86.1 | 19 | 95.0 | |
| TNM Stage | |||||
| I–II | 24 | 66.7 | 20 | 100 | <0.01 |
| III–IV | 12 | 33.3 | 0 | 0 | |
| Tumor regression gradea | |||||
| 1a | 11 | 30.6 | 6 | 30.0 | 0.94 |
| 1b | 11 | 30.6 | 7 | 35.0 | |
| 2 | 14 | 38.9 | 7 | 35.0 | |
SD, standard deviation; Pap, Papillary adenocarcinoma; Well, Well differentiated adenocarcinoma; Mod, Moderately differentiated adenocarcinoma; Por, Poorly differentiated adenocarcinoma; Muc, Mucinous adenocarcinoma; LRG5, Leucine-rich repeat-containing G protein-coupled receptor 5, TNM, tumor node metastasis
a
According to Japanese Classification of Colorectal Carcinoma, 8 th edition.