Table 2.
Observed side effects in 90 patients with narcolepsy with cataplexy treated with sodium oxybate.
| n (%) | |
|---|---|
| General | |
| Amenorrhea | 1 (1.1%) |
| Appetite loss | 6 (6.6%) |
| Asthenia | 1 (1.1%) |
| Bad taste | 6 (6.6%) |
| Facial swelling | 1 (1.1%) |
| Pain | 4 (4.4%) |
| Peripheral edema | 1 (1.1%) |
| Sweating | 3 (3.3%) |
| Urinary incontinence | 2 (2.2%) |
| Psychiatric | |
| Anxiety | 4 (4.4%) |
| Hallucinations | 2 (2.2%) |
| Mood swings | 14 (15.5%) |
| Psychosis | 3 (3.3%) |
| Suicidal ideation | 1 (1.1%) |
| Cardiac | |
| Hypertension | 1 (1.1%) |
| Palpitations | 1 (1.1%) |
| Infections | |
| Viral infection | 1 (1.1%) |
| Gastrointestinal | |
| Diarrhea | 1 (1.1%) |
| Dry mouth | 1 (1.1%) |
| Faecal incontinence | 1 (1.1%) |
| GERD | 2 (2.2%) |
| Nausea | 16 (17.7%) |
| Vomit | 6 (6.6%) |
| Neurological | |
| Cramps | 1 (1.1%) |
| Dizziness | 9 (9.9%) |
| Headaches | 7 (7.7%) |
| Impaired concentration | 6 (6.6%) |
| Myoclonus | 1 (1.1%) |
| Unresponsiveness | 4 (4.4%) |
| Sleep disorders | |
| Enuresis | 11 (12.2%) |
| Insomnia | 2 (2.2%) |
| Sleep walking | 7 (7.7%) |
| Worse cataplexy | 1 (1.1%) |
| Worse OSA | 3 (3.3%) |
GERD: gastroesophageal reflex disease, OSA: obstructive sleep apnea.