Table 1.
Genotype and allele distributions for the TNFR1 (rs4149576, rs4149577, and rs1860545) polymorphisms in paranoid schizophrenia patients (n = 388) and control subjects (n = 657).
| Polymorphisms | N (%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Genotype | Allele | ||||||||
| rs4149576 | T/T | C/T | C/C | χ 2 | p | T | C | χ 2 | p |
| Patients | 108 (28) | 190 (49) | 90 (23) | 0.34 | 0.84 | 406 (52) | 370 (48) | 0.35 | 0.55 |
| Control | 174 (26) | 322 (49) | 161 (25) | 670 (51) | 644 (49) | ||||
| Male patients | 64 (27) | 114 (48) | 59 (25) | 0.68 | 0.71 | 242 (51) | 232 (49) | 0.34 | 0.55 |
| Male controls | 82 (24) | 172 (50) | 88 (26) | 336 (49) | 348 (51) | ||||
| Female patients | 44 (29) | 76 (50) | 31 (21) | 0.47 | 0.78 | 164 (54) | 138 (46) | 0.08 | 0.76 |
| Female controls | 92 (29) | 150 (48) | 73 (23) | 334 (53) | 296 (47) | ||||
| rs4149577 | A/A | A/G | G/G | χ 2 | p | A | G | χ 2 | p |
| Patients | 122 (31) | 201 (52) | 65 (17) | 3.07 | 0.21 | 445 (57) | 331 (43) | 0.02 | 0.88 |
| Control | 222 (33) | 305 (46) | 130 (19) | 749 (57) | 565 (43) | ||||
| Male patients | 72 (30) | 121 (51) | 44 (19) | 0.40 | 0.81 | 265 (56) | 209 (44) | 0.04 | 0.83 |
| Male controls | 105 (31) | 167 (49) | 70 (20) | 377 (55) | 307 (45) | ||||
| Female patients | 50 (33) | 80 (53) | 21 (14) | 3.8 | 0.14 | 180 (60) | 122 (40) | 0.03 | 0.88 |
| Female controls | 117 (37) | 138 (44) | 60 (19) | 372 (59) | 258 (41) | ||||
| rs1860545 | G/G | G/A | A/A | χ 2 | p | A | G | χ 2 | p |
| Patients | 96 (25) | 193 (50) | 99 (26) | 0.79 | 0.67 | 391 (50) | 385 (50) | 0.69 | 0.41 |
| Control | 174 (26) | 330 (51) | 153 (23) | 636 (48) | 678 (52) | ||||
| Male patients | 62 (26) | 115 (49) | 60 (25) | 0.91 | 0.63 | 235 (50) | 239 (50) | 0.60 | 0.43 |
| Male controls | 95 (28) | 172 (50) | 75 (22) | 322 (47) | 362 (53) | ||||
| Female patients | 34 (23) | 78 (52) | 39 (26) | 0.36 | 0.83 | 156 (52) | 146 (48) | 0.20 | 0.65 |
| Female controls | 79 (25) | 158 (50) | 78 (25) | 314 (50) | 316 (50) | ||||