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. 2017 Nov 28;2017:4139439. doi: 10.1155/2017/4139439

Figure 4.

Figure 4

Effects of gemigliptin pretreatment on cisplatin-induced apoptotic cell death in the kidneys. (a) TUNEL staining (×200). (b) The number of TUNEL-positive cells in 5 fields (×200). (c) Western blot analysis of the expression of Bax, cleaved caspase-3, cleaved PARP-1, and β-actin in the kidneys. The graphs showing the results of quantitative analysis of Bax (d), cleaved caspase-3 (e), and cleaved PARP-1 (f) among groups. Con: control, n = 6; CP: cisplatin, n = 6; and CP + G: cisplatin + gemigliptin, n = 6. All data are expressed as the mean ± SEM. #P < 0.01 versus Con and ∗P < 0.01 versus CP.