Table 3.
Multivariate regression models for associations between HLA-matching status and clinical outcome in PTCy regimens
| aGVHD ≥2 | cGVHD | TRM | Relapse | OS | LFS | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| HLA-matching status at the antigenic level | ||||||||||||
| HLA-A, mismatch vs match | 0.7 (0.4-1.1) | .14 | 0.9 (0.5-1.7) | .80 | 0.7 (0.4-1.1) | .14 | 1.3 (0.7-2.3) | .38 | 0.9 (0.6-1.3) | .48 | 0.9 (0.6-1.4) | .65 |
| HLA-B, mismatch vs match | 0.8 (0.4-1.5) | .51 | 1.4 (0.6-3.4) | .45 | 1.9 (0.7-4.9) | .20 | 0.7 (0.4-1.5) | .39 | 1.2 (0.6-2.1) | .62 | 1.1 (0.6-1.9) | .79 |
| HLA-C, mismatch vs match | 1.1 (0.6-2) | .70 | 1.6 (0.8-3.4) | .21 | 0.9 (0.5-1.9) | .87 | 1.5 (0.8-2.8) | .25 | 1.2 (0.7-2) | .49 | 1.2 (0.7-1.9) | .47 |
| HLA-DRB1, mismatch vs match | 2 (1.2-4) | .03* | 0.8 (0.5-1.4) | .40 | 0.7 (0.4-1.2) | .18 | 1.4 (0.8-2.6) | .25 | 1 (0.6-1.5) | .89 | 1 (0.7-1.6) | .84 |
| Leukemia diagnosis, ALL vs AML | — | — | — | — | 1.7 (1-2.8) | .06 | 1.5 (0.9-2.5) | .10 | 1.8 (1.2-2.6) | <10−2* | 1.5 (1.1-2.2) | .03* |
| Disease status, advanced vs CR1 | — | — | — | — | 1.7 (1.1-2.9) | .05* | 5.2 (3-9.1) | <10−5* | 3.4 (2.3-5.1) | <10−5* | 3 (2-4.4) | <10−5* |
| Stem cell source, PB vs BM | 2.2 (1.4-3) | <10−2* | — | — | — | — | — | — | — | — | — | — |
| Donor sex, female vs male | 1.7 (1.1-2.8) | .04* | — | — | — | — | 0.6 (0.4-0.9) | .04* | 0.7 (0.5-0.9) | .04* | 0.7 (0.5-0.9) | .03* |
| CMV status, neg/neg vs other | — | — | — | — | — | — | — | — | — | — | — | — |
| Conditioning intensity, RIC vs MAC | 0.6 (0.4-0.9) | .04* | — | — | — | — | — | — | — | — | — | — |
| Recipient age, 10-y intervals | — | — | — | — | 1.2 (1-1.4) | .05 | — | — | — | — | — | — |
| HLA-matching status at the allelic level | ||||||||||||
| HLA-A, mismatch vs match | 0.7 (0.4-1.5) | .42 | 0.9 (0.4-2.2) | .87 | 1.3 (0.5-3.2) | .54 | 1.3 (0.6-3) | .48 | 1.4 (0.7-2.7) | .31 | 1.3 (0.7-2.3) | .45 |
| HLA-B, mismatch vs match | 0.6 (0.2-1.5) | .26 | 2.2 (0.5-9.3) | .26 | 1.1 (0.3-4) | .89 | 1.1 (0.4-3.5) | .80 | 0.9 (0.4-2.2) | .86 | 1.2 (0.5-2.7) | .73 |
| HLA-C, mismatch vs match | 2.8 (0.9-8.8) | .06 | 1.4 (0.4-4.3) | .58 | 1.8 (0.5-6) | .35 | 1.4 (0.6-3.6) | .44 | 1.6 (0.8-3.5) | .22 | 1.6 (0.8-3.2) | .22 |
| HLA-DRB1, mismatch vs match | 1.3 (0.4-3.4) | .60 | 1.4 (0.5-3.8) | .54 | 0.6 (0.3-1.2) | .13 | 1.2 (0.5-3.1) | .68 | 0.7 (0.4-1.4) | .35 | 0.9 (0.5-1.5) | .54 |
| Leukemia diagnosis, ALL vs AML | — | — | — | — | 1.9 (1-3.4) | .05* | 1.5 (0.8-3.1) | .13 | 1.9 (1.2-3) | <10−2* | 1.7 (1.1-2.5) | .02* |
| Disease status, advanced vs CR1 | — | — | — | — | 1.3 (0.7-2.4) | .36 | 5.2 (2.7-9.7) | <10−4* | 2.9 (1.9-4.5) | <10−4* | 2.6 (1.7-4) | <10−4* |
| Stem cell source, PB vs BM | 2.8 (1.7-4.7) | <10−2* | — | — | — | — | — | — | — | — | — | — |
| Donor sex, female vs male | 1.8 (1-3.2) | .05* | — | — | — | — | 0.6 (0.4-0.9) | .03* | 0.6 (0.4-0.8) | .02* | 0.6 (0.4-0.8) | .02* |
| CMV status, neg/neg vs other | — | — | — | — | — | — | — | — | — | — | — | — |
| Conditioning intensity, RIC vs MAC | 0.6 (0.3-0.9) | .04* | — | — | — | — | — | — | — | — | — | — |
| Recipient age, 10-y intervals | — | — | — | — | 1.3 (1-1.4) | .05 | — | — | — | — | — | — |
Results for HLA matching were adjusted for the covariates listed.
—, Specific clinical variable was not significant in the multivariate model for the examined endpoint.
*
Statistically significant values.