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A) The solvent exposed binding site of E-selectin interacting with sLex (PDB: 1G1T) [53]. B) The buried binding site of FimHLD in complex with a high-mannose epitope and a conserved water (blue sphere) (PDB: 2VCO) [36]. C) The buried ligand surface area of analyzed crystal structures correlates to affinity [μM] on a logarithmic scale (for references see Table 1). The rabbit and turtle metaphor was adapted from Schmidtke et al. [50].
