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. 2017 Dec 12;17:841. doi: 10.1186/s12885-017-3851-y

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Kaplan-Meier survival curves for overall survival of GC patients. Following clinical parameters have no association with OS: differentiation (a), depth of invasion (b), lymph node metastasis (c) and TNM stage (d). However, overexpression of HER family members, such as HER3 (P = 0.001, f) and HER2-HER3 co-expression (P = 0.005, h) are significantly related to overall survival rate of GC patients. Akt (i), p-Akt (j) and mTOR (k) are not associated with OS. Meanwhile, p-mTOR (l) has tight link with overall survival (P = 0.006)