Table 2.

Association between clinicopathological parameters, proteins and HER2, HER3, HER2-HER3 co-expression in 120 cases of gastric cancer

		Total patients	HER2-positive	HER2-negative	P value	HER3-positive	HER3-negative	P value	HER2/HER3 co-expression	P value
Sex	Male	80	19	61	0.88	42	38	0.60	16	0.75
	Female	40	10	30		23	17		9
Age	<60y	49	9	40	0.02	24	25	0.34	7	0.14
	>60y	71	20	51		41	30		18
Tumor size	<3 cm	15	4	11	1.00	7	8	0.53	4	0.80
	>3 cm	105	25	80		58	47		21
Differentiation	Well/moderate	102	20	82	0.01	52	50	0.10	17	0.02
	Poor	18	9	9		13	5		8
Tumor location	Upper/Medium	77	17	60	0.47	42	35	0.91	16	0.98
	Low	43	12	31		23	20		9
Depth of invasion	T1 + T2	22	4	18	0.47	7	15	0.02	2	0.23
	T3 + T4	98	25	73		58	40		23
Lymph node metastasis	N0	25	6	19	0.98	11	14	0.25	6	0.59
	N1 + N2 + N3	95	23	72		54	41		19
Metastasis	M0	114	25	89	0.045	62	52	1.00	23	0.80
	M1	6	4	2		3	3		2
TNM stage	I + II	33	5	28	0.16	17	16	0.72	5	0.35
	III + IV	87	24	63		48	39		20