Table 7.
Meta-analysis of association between HER family members, pathway-related proteins expression and OS
| Proteins | Tumor location | OS | Number of studies | Number of patients | Heterogeneity | Model | RR(95%CI) | P value | |
|---|---|---|---|---|---|---|---|---|---|
| I 2 (%) | P value | ||||||||
| HER2-HER3 | Digestive tract | 1-year OS | 5 | 969 | 48 | 0.11 | FE | 0.71(0.36,1.40) | 0.32 |
| 3-year OS | 5 | 969 | 0 | 0.48 | RE | 1.27(0.98,1.64) | 0.07 | ||
| 5-year OS | 4 | 847 | 66 | 0.03 | RE | 1.31(1.00,1.72) | 0.049 | ||
| HER3 | Stomach | 1-year OS | 6 | 888 | 14 | 0.33 | FE | 1.85(1.32,2.58) | <0.001 |
| 3-year OS | 5 | 813 | 46 | 0.12 | FE | 1.53(1.27,1.85) | <0.001 | ||
| 5-year OS | 3 | 503 | 85 | 0.001 | RE | 2.18(1.15,4.14) | 0.02 | ||
| Akt | Stomach | 1-year OS | 1 | 98 | – | – | – | 2.09(0.50,8.83) | 0.32 |
| 3-year OS | 1 | 98 | – | – | – | 1.59(0.73,3.43) | 0.24 | ||
| 5-year OS | 1 | 98 | – | – | – | 1.43(1.06,1.03) | 0.02 | ||
| p-Akt | Stomach | 1-year OS | 8 | 1558 | 66 | 0.004 | RE | 0.96(0.56,1.65) | 0.89 |
| 3-year OS | 8 | 1558 | 75 | 0 | RE | 1.19(0.84,1.69) | 0.32 | ||
| 5-year OS | 7 | 1513 | 79 | 0 | RE | 1.15(0.84,1.58) | 0.37 | ||
| mTOR | Stomach | 1-year OS | 3 | 1179 | 90 | 0 | RE | 1.02(0.38,1.2.73) | 0.97 |
| 3-year OS | 3 | 1179 | 89 | 0 | RE | 1.06(0.62,1.81) | 0.82 | ||
| 5-year OS | 3 | 1179 | 94 | 0 | RE | 1.02(0.65,1.61) | 0.94 | ||
| p-mTOR | Stomach | 1-year OS | 7 | 2269 | 0 | 0.75 | FE | 1.86(1.50,2.31) | <0.001 |
| 3-year OS | 7 | 2269 | 48 | 0.07 | FE | 1.71(1.52,1.93) | <0.001 | ||
| 5-year OS | 7 | 2269 | 70 | 0.003 | RE | 1.53(1.26,1.86) | <0.001 | ||
OS overall survival, RR risk ratio, CI confidence interval, FE fixed-effect model, RE random-effect model