Table 3.
Hazard ratio (HR) of incident colorectal- and colon cancer associated with blood glucose for men and women in the Malmö Diet and Cancer Study cardiovascular cohort
| Colorectal cancer nmen = 1992 nwomen = 2981 |
Colon cancer nmen = 1958 nwomen = 2888 |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Crude model | Full model | Crude model | Full model | ||||||||
| Quartiles of glucose | Min-max (mIU/l) | Cases/person-years | HR | 95% CI | HR | 95% CI | Cases/person-years | HR | 95% CI | HR | 95% CI |
| Men | |||||||||||
| 1 | 3.3–4.5 | 5/4400 | 1.00 | 1.00 | 2/4358 | 1.00 | 1.00 | ||||
| 2 | 4.6–4.8 | 10/7276 | 1.28 | 0.57, 2.90 | 1.25 | 0.55, 2.85 | 4/7216 | 2.05 | 0.50, 7.01 | 1.95 | 0.57, 6.70 |
| 3 | 4.9–5.2 | 16/9835 | 2.10 | 0.99, 4.45 | 2.03 | 0.95, 4.32 | 9/9767 | 2.28 | 0.67, 7.79 | 2–08 | 0.60, 7.17 |
| 4 | 5.3–16.8 | 40/10853 | 3.08 | 1.54, 6.15 | 2.80 | 1.37, 5.70 | 22/19679 | 5.40 | 1.84, 15.87 | 4.23 | 1.46, 13.44 |
| p for trend | <0.001 | 0.001 | 0.001 | 0.002 | |||||||
| Women | |||||||||||
| 1 | 3.4–4.5 | 20/13981 | 1.00 | 1.00 | 12/13888 | 1.00 | 1.00 | ||||
| 2 | 4.6–4.8 | 20/14048 | 1.24 | 0.64, 2.38 | 1.21 | 0.62, 2.34 | 9/13977 | 0.77 | 0.29, 2.05 | 0.73 | 0.27, 1.96 |
| 3 | 4.9–5.2 | 18/12553 | 0.89 | 0.47, 1.66 | 0.82 | 0.44, 1.55 | 13/12510 | 1.08 | 0.50, 2.34 | 0.96 | 0.45, 2.09 |
| 4 | 5.3–12.2 | 16/8834 | 1.16 | 0.62, 2.17 | 1.02 | 0.53, 1.95 | 10/8797 | 1.22 | 0.54, 2.71 | 1.01 | 0.44, 2.34 |
| 0.908 | 0.739 | 0.562 | 0.878 | ||||||||
Full model: Calculated with the Cox proportional hazard regression model. Adjusted for age (quartiles of age), BMI (≤ 25 kg/m2, > 25 kg/m2), and smoking (current, ex or never)
Values are quartile ranges, hazard ratios (HR), and 95% confidence intervals (CI)