Fig. 3.

Overexpression of PTPN6 inhibited PDCD4 expression levels both in vitro and in vivo. a expression of PTPN6, PDCD4, BAX and APP in mouse lungs exposed to Al₂O₃ NPs (n = 10, ^* P < 0.05, ^** P < 0.01, ^*** P < 0.001). b mRNA and protein expression levels of PTPN6, PDCD4, BAX and APP in A549 and HBE cells (n = 6, ^* P < 0.05, compared with vehicle-treated control, ^** P < 0.01, compared with vehicle-treated control, ^*** P < 0.001, compared with vehicle-treated control, ^## P < 0.01, compared with vehicle/Al₂O₃ NPs-exposed group, ^### P < 0.001, compared with vehicle/Al₂O₃ NPs-exposed group). c Representative images of PDCD4 expression in mouse lung tissues. LTV: lentivirus; OEX: overexpression