Table 2.
Assessment of prediction scores
| Total | Survivors | Non-survivors | AUC | 95% CI | p value | Hosmer–Lemeshow statistic (χ2; p value) | Pairwise comparison to PRESET-Score (difference between areas; p value) | |
|---|---|---|---|---|---|---|---|---|
| Derivation cohort (n) | 108 | 41 | 67 | |||||
| ECMOnet-Score | 4.5 (3; 6) | 4 (3; 5) | 5 (4; 7) | 0.695 | 0.59–0.79 | 0.001 | 3.7; 0.876 | 0.127; 0.0260 |
| RESP-Score | –1 (–6; 3) | 1 (–3; 4) | –2 (–7; 2) | 0.645 | 0.53–0.75 | 0.012 | 8.4; 0.395 | 0.178; 0.0045 |
| PRESERVE-Score | 4 (3; 6) | 4 (2; 5) | 5 (3; 6) | 0.593 | 0.48–0.71 | 0.106 | 5.2; 0.396 | 0.230; 0.0010 |
| Roch-Score | 3 (3; 4) | 3 (2; 4) | 3 (3; 4) | 0.564 | 0.45–0.68 | 0.269 | 5.4; 0.020 | 0.259; 0.0003 |
| PRESET-Score | 7 (5; 10) | 5 (4; 7) | 8 (7; 11) | 0.823 | 0.74–0.90 | < 0.001 | 2.9; 0.940 | |
| Internal validation cohort (n) | 82 | 37 | 45 | |||||
| PRESET-Score | 6 (5; 10) | 4 (4; 6) | 8 (6; 11) | 0.845 | 0.76–0.93 | < 0.001 | 10.9; 0.207 | |
| External validation cohort (n) | 59 | 31 | 28 | |||||
| PRESET-Score | 7 (5; 9) | 6 (4; 8) | 8 (7; 10) | 0.700 | 0.56–0.83 | 0.008 | 4.2; 0.655 |
Variables presented as median (first quartile; third quartile)
ARDS acute respiratory distress syndrome, AUC area under the curve, CI confidence interval, ECMO extracorporeal membrane oxygenation, PRESERVE-Score Predicting Death for Severe ARDS on VV-ECMO, PRESET-Score PREdiction of Survival on ECMO Therapy-Score, VV veno-venous