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. 2017 Dec 12;18:81. doi: 10.1186/s40360-017-0187-9

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — a Shown are the measured ibuprofen plasma concentration (IPC) (), creatinine-level (--) and predicted IPC () over time (from ICU admission until day 5). TPE () was applied for about one hour. For simulation of early phase disposition, a one-compartment model with bolus input and 1st order elimination rate was used [C=Co * e(exp(-k * t)); Phoenix WinNonlin 6.3, Pharsight, Mountain View, CA]. This model provided an almost “pseudo-normal” elimination half-life of 5.1 h. b Shown are the applied norepinephrine dose () in relation to the blood pH (--) over time. Acidosis improvement was not correlated with the norepinephrine dose (b). c Measured ibuprofen plasma concentration (IPC) () and predicted IPC () over time (from ICU admission until day 5, linear x-axis). For estimation of the overall elimination rate, a non-compartmental analysis (NCA) was performed. Within the NCA model a linear trapezoidal calculation method with linear interpolation was used. The NCA model provided an estimated overall elimination half-life of 17.2 h

Inline graphic — a Shown are the measured ibuprofen plasma concentration (IPC) (), creatinine-level (--) and predicted IPC () over time (from ICU admission until day 5). TPE () was applied for about one hour. For simulation of early phase disposition, a one-compartment model with bolus input and 1st order elimination rate was used [C=Co * e(exp(-k * t)); Phoenix WinNonlin 6.3, Pharsight, Mountain View, CA]. This model provided an almost “pseudo-normal” elimination half-life of 5.1 h. b Shown are the applied norepinephrine dose () in relation to the blood pH (--) over time. Acidosis improvement was not correlated with the norepinephrine dose (b). c Measured ibuprofen plasma concentration (IPC) () and predicted IPC () over time (from ICU admission until day 5, linear x-axis). For estimation of the overall elimination rate, a non-compartmental analysis (NCA) was performed. Within the NCA model a linear trapezoidal calculation method with linear interpolation was used. The NCA model provided an estimated overall elimination half-life of 17.2 h