Table 1.
Characteristics of the entire analytic sample and by genotype severity
| Entire analytic sample | “Severe” genotype | “Moderate” genotype | P* | |
|---|---|---|---|---|
| Mean (SD)* (n = 88) | Mean (SD)* (n = 56) | Mean (SD)* (n = 32) | ||
| Age, y | 36.3 (12.0) | 33.7 (10.8) | 40.9 (12.8) | .006 |
| Male sex, n (%)* | 33 (37.5) | 21 (37.5) | 12 (37.5) | .97 |
| Education, y | 13.1 (1.7) | 13.1 (1.8) | 13.2 (1.7) | .78 |
| MCI, n (%) | 20 (22.7) | 17 (30.4) | 3 (9.4) | .14 |
| DSST T-score | 46.3 (11.7) | 47.6 (14.5) | 51.0 (13.4) | .004 |
| O2 saturation, % | 97.8 (1.8) | 97.5 (1.8) | 98.1 (1.7) | .15 |
| WBC count, ×109/L | 9.5 (3.7) | 9.7 (3.8) | 9.2 (3.7) | .86 |
| Hemoglobin, g/dL | 10.0 (1.9) | 9.2 (1.5) | 11.5 (1.5) | <.0001 |
| Platelet count, ×109/L | 314.0 (162.8) | 344.1 (179.8) | 263.3 (115.1) | .17 |
| Reticulocytes, % | 1.5 (3.4) | 1.7 (4.0) | 1.1 (1.9) | .49 |
| LDH, IU/L | 302.8 (146.0) | 321.2 (142.3) | 269.2 (149.1) | .16 |
| Ferritin, ng/mL | 892.6 (1664.3) | 1141.6 (1864.4) | 403.4 (1042.2) | .02 |
| Creatinine, mg/dL | 0.7 (0.2) | 0.7 (0.3) | 0.8 (0.2) | .91 |
| SBP, mm/Hg | 114.2 (13.9) | 111.3 (13.4) | 118.9 (13.6) | .08 |
| DBP, mm/Hg | 70.6 (8.8) | 68.8 (7.7) | 73.5 (9.8) | .02 |
| MAP, mm/Hg | 85.2 (9.4) | 83.1 (8.4) | 88.6 (10.0) | .01 |
| Hydroxyurea use, n (%) | 42 (47.7) | 32 (57.1) | 10 (31.2) | .04 |
| Opiate use, n (%) | 25 (28.4) | 15 (26.8) | 10 (31.2) | .57 |
| Transfusion history, n (%) | 22 (25.9) | 17 (31.5) | 5 (16.1) | .15 |
| Stroke history, n (%) | 11 (12.5) | 9 (16.1) | 2 (6.3) | .13 |
| SCI history, n (%) | 4 (4.5) | 3 (5.4) | 1 (3.1) | .65 |
*
Age-adjusted P value calculated with linear regression for continuous variables and logistic regression for categorical variables; the models with age were unadjusted, and the models with standardized DSST T-score were unadjusted. The bold font indicates P < .05.