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. Author manuscript; available in PMC: 2018 Nov 16.
Published in final edited form as: Mol Cell. 2017 Nov 9;68(4):808–820.e5. doi: 10.1016/j.molcel.2017.10.015

Figure 7. SG-enriched mRNAs are enriched for SG-resident proteins.

Figure 7

(A) Survey of RNA binding proteins from Nostrand et al. (2016)) plotted against the fraction of eCLIP sites found in SG-enriched mRNAs. Green dots are SG-resident RBPs. Black dots are non-SG resident RBPs. Green dots with a red diagonal line are SG-resident RBPs with PrLD domain. Green dots with a red X are SG-resident RBPs with PrLD domain and are associated with ALS/FTD. Box plot illustrating the fraction of eCLIP sites found in (B) SG-enriched mRNAs or (C) SG-depleted mRNAs from SG-resident RBPs or non-SG RBPs. Box plot depicting the fraction of eCLIP sites found in SG-depleted mRNAs from SG-RBPs or non-SG RBPs. Box plot illustrating the fraction of eCLIP sites found in SG-enriched RNAs from (D) SG-RBPs containing PrLD and (E) RBPs associated with ALS/FTD. * and ** = p value (Student’s t-test) ≤0.05, and ≤0.01 respectively.