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. Author manuscript; available in PMC: 2018 Nov 13.
Published in final edited form as: Cancer Cell. 2017 Nov 13;32(5):574–589.e6. doi: 10.1016/j.ccell.2017.10.007

Figure 6. Partial and complete Arid1a loss increased chromatin occupancy and altered gene expression to similar extents.

Figure 6

(A) ARID1A protein expression in LAP-MYC tumors.

(B) ATAC-seq peaks in LAP-MYC; Arid1a WT (n = 4), Het (n = 4), and Homo (n = 3) tumors. Total peaks called are in parentheses.

(C) 3256 ATAC-seq peaks uniquely called in WT tumors are visualized here.

(D) The global view of chromatin accessibility for these 3256 tracks.

(E) RNA-seq of LAP-MYC; Arid1a WT (n = 4), Het (n = 4), and Homo (n = 4) tumors from pure FVB mice. Of 634 differentially expressed genes, 193 were up and 442 were downregulated.

(F) ATAC-seq peaks for 153 genes that are differentially expressed after Arid1a loss. See also Table S3.